Launch of Bright Angel Therapeutics

New York, NY and Toronto Canada, Dec. 21, 2017 (GLOBE NEWSWIRE) — Schrödinger, Inc., a privately-held company dedicated to revolutionizing drug discovery through advanced computational methods, and MaRS Innovation, a non-profit organization supporting the commercialization of research breakthroughs from Toronto’s leading academic institutions, today announced the launch of Bright Angel Therapeutics. The new Toronto-based company is focused on the development of novel therapeutics for treatment of drug-resistant and life-threatening fungal infections. Bright Angel’s first program is based on foundational research from the lab of the late Susan Lindquist, Ph.D., former Director and Member of the Whitehead Institute.

“Antifungal resistance is a serious unaddressed problem that affects patients around the globe. Diagnosis of invasive fungal infections is often difficult, and these life-threatening infections can be difficult if not impossible to cure with current treatments,” said Dominic Jaikaran, Ph.D., Bright Angel’s Chief Executive Officer. “We’re pleased to continue Dr. Lindquist’s work and to partner with Schrödinger to bring a fresh approach to drug discovery and speed the development of effective treatments for this emergent world health issue.”

“We are excited to work alongside Bright Angel’s world-renowned mycology experts to address this serious unmet medical need in the infectious disease space,” said Ramy Farid, Ph.D., Schrödinger’s President and Chief Executive Officer. “We are confident that our platform technologies will accelerate the pace of drug discovery at Bright Angel, and we look forward to collaborating closely with the team to advance potential novel therapeutics efficiently through development.”

Under the terms of the agreement, Schrödinger will leverage its state-of-the-art in silico drug discovery platforms in up to three joint programs to design and develop fungal-selective compounds. MaRS Innovation will provide its suite of start-up services including initial management and strategy, as well as financial and legal support. Schrödinger and MaRS Innovation are equity owners in Bright Angel. Additional details and financial terms of the agreement were not disclosed.

Dr. Lindquist, together with Dr. Leah Cowen, now Chair and Professor of Molecular Genetics at the University of Toronto, was the first to show that the molecular chaperone Hsp90 plays a central role in antifungal resistance mechanisms. Bright Angel aims to build upon this research breakthrough to develop a fungal-specific Hsp90 inhibitor that will be used in combination with existing standards of care to overcome the frequent emergence of clinical resistance largely responsible for the severe morbidity and mortality associated with infection by diverse fungal pathogens.

“The partnership between Schrödinger and Bright Angel is the fruitful realization of MaRS Innovation’s aim to create important strategic partnerships to better advance our Members’ technologies,” said Dr. Raphael Hofstein, President and CEO of MaRS Innovation. “The collaboration with Schrödinger will not only assist in ensuring success for Bright Angel but is also a validation of the stellar science coming from our Members.”

Alongside Schrödinger and MaRS Innovation, the company’s co-founders include Dr. Cowen and Dr. Luke Whitesell, who discovered the first inhibitor of Hsp90 and also played a central leadership role for over a decade in the Lindquist Lab at Whitehead Institute. Dr. Whitesell has recently relocated to Toronto to join the Bright Angel team and to drive promising academic programs in Dr. Cowen’s Antifungal Research Group at the University of Toronto to a point where Bright Angel can engage to bring them forward as candidates for clinical development.

About Schrödinger

Schrödinger is a leading provider of advanced molecular simulations and enterprise software solutions and services.  Its technologies accelerate and increase the efficiency of drug discovery for its clients, which include all major pharmaceutical and biotechnology companies worldwide, as well as leading materials science researchers. Schrödinger also establishes deep partnerships and collaborations with companies in such fields as biotechnology, pharmaceuticals, chemicals, and electronics. It is a cofounder of leading biotech companies including Nimbus Therapeutics, Morphic Therapeutic, Bright Angel Therapeutics, and others. Schrödinger’s investors include David E. Shaw and Bill Gates. Through significant long-term investments in basic research, Schrödinger has made scientific breakthroughs across many areas of drug discovery and materials science. Hundreds of peer-reviewed scientific publications by Schrödinger scientists are frequently among the most heavily cited in their fields. Founded in 1990, Schrödinger has over 300 employees and operations in the United States, Europe, Japan, and India, as well as business partners in China and Korea. For more information, please visit www.schrodinger.com.

About MaRS Innovation

MaRS Innovation is a leading provider of commercialization services, early-stage funding, and deal-brokering with industry and private investors. As a member-based organization made up of 14 of Toronto’s top universities, institutions, research institutes, and MaRS Discovery District, MaRS Innovation’s mandate is to drive the commercialization of their most promising research breakthroughs.

MaRS Innovation’s portfolio consists of early-stage assets and companies. Our team leverages its deep expertise and experience to mature our portfolio via important global and strategic partnerships. With an active portfolio of more than 40 companies which have raised in excess of $200M from global investors, and with the creation of more than 400 direct jobs, MaRS Innovation is truly a leader in the commercialization field.  For more information, please visit www.marsinnovation.com.

Contacts:
Dominic Jaikaran, CEO Bright Angel
MaRS Innovation
647 260 8898
djaikaran@marsinnovation.com

Shi-Yi Liu, Ph.D
Schrodinger
503 299 1150, x.108
shu-yi.liu@schrodinger.com

Christina Tartaglia
Stern Investor Relations, Inc.
212 362 1200
christina@sternir.com